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Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13 (1), 332336.

More detailed body scans in clinical trials show that a fraction of the weight lost (a few percent) is from lean tissue, including muscle

Five to ten percent of patients discontinued the drug across doses, the company said, which was one of two late-stage trials the drug must pass before being submitted for federal approval

The main mechanism underlying this phenomenon is the loss of the suppressive activity of insulin to regulate lipolysis in a metabolic dysregulated visceral adipose tissue, even during times of nutrient excess [17]

However, a closer look reveals that these medications frequently fail to live up to the hype